The Ætiology of 'Phrynoderma'

Treatment of Phrynoderma by Vitamin-A Concentrate

Phrynoderma (toad-skin) is the name given to a papulo-follicular dermatosis commonly seen in malnourished individuals (Nicholls, 1933). During recent years considerable attention has been paid by nutrition workers to the study of the condition. A brief review of the literature on the subject and an account of its clinical and anatomical features have been given in a previous communication (Radh...

Phrynoderma and Some Associated Changes in Blood Lipids *Preliminary results on the blood lipid analysis of twenty-two cases of phrynoderma and eight normal individuals were communicated in an Abstract to the Indian Science Congress Association, Poona, 1950.

nutritional deficiency. This condition has been used as a convenient sign in routine nutritional surveys in India as an index of vitamin A deficiency. Rao (1937) has described the histopathology of phrynoderma and has brought out evidence that it is due to vitamin A deficiency. A nutritional survey carried out in Malabar (India) by Aykroyd and Rajagopal (1936), however, cast some doubt on the g...

Phrynoderma: a forgotten entity in a developed country.

Phrynoderma is a type of follicular hyperkeratosis attributed to various nutritional deficiencies, most notably vitamin A. We report a case of a 31-year-old mentally-deficient man who was a resident of a voluntary welfare nursing home. He presented with characteristic hyperkeratotic follicular papules on his trunk in a setting of low serum level of vitamin A and malnutrition. Although commonly ...

The Long Fox Memorial Lecture: The Ætiology of Cardiac Disease

Role of vitamin E in the aetiology of phrynoderma (follicular hyperkeratosis) and its interrelationship with B-complex vitamins.

1. A study was undertaken to investigate the role of vitamin E in the aetiology of phrynoderma (follicular hyperkeratosis). Fifty-six children with the disease and twenty-one normal children were investigated for this purpose. 2. Plasma vitamin E levels (mean +/- SE; mg/l) were found to be low in phrynoderma (3.7 +/- 0.19) in contrast with normal children (6.6 +/- 0.40) and therapy with a combi...